HIV Disease in Women and Children

A special issue on prevention and treatment of pregnant women and their offspring

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EDITORIAL

Preventing Vertical Transmission: A Wise Investment

We have learned a lot about how to prevent transmission of HIV from mother to their infants, and the time to act is now
CATHERINE M. WILFERT, M.D.

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OPTIMAL MEDICAL MANAGEMENT

Antiretroviral Therapy in Pregnant Women

Treatment reduces the likelihood of vertical transmission as well as maternal disease progression
BONNIE J. DATTEL, M.D.

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NEWSLINE

Newsline ... Newsline ... Newsline ...

Combinations of reverse transcriptase inhibitors in children: A small study shows ZDV plus 3TC to be effective in patients who fail monotherapy ... Triple combination therapy in infants: Compelling evidence of the efficacy of early, aggressive therapy in neonates ... Risk factors and perinatal transmission: Data suggest that therapeutic strategies should emphasize reduction of viral load ... Oral ZDV may be equal to intravenous drug during delivery: Both achieve dramatic reductions in perinatal transmission rates ... Low-dose ZDV is effective in children: Optimal dose appears to be 90 mg/m² or less ... Glaxo Wellcome makes its promising new nucleoside analog, abacavir (GW1592), available to children as well as adults ...

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PULL OUT AND SAVE

U.S. Public Health Service Recommendations for Use of Antiretroviral Drugs During Pregnancy

Highlights of a task force report aimed at optimizing maternal health and reducing perinatal transmission of HIV infection

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THERAPEUTIC ADVANCES

Antiretroviral Therapy in Children

The pediatric standard of care -- especially with regard to the use of protease inhibitors -- is a crazy quilt of guesswork and hopeful comparisons
PHILIP TOLTZIS, M.D., AND TIFFANI COLEMAN, R.N., N.D.